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The suppression of big WT1 isoform-mediated transcriptional activation by Ex4a(+) WT1 could possibly be prolonged to other direct transcriptional targets also as Bcl-xL and Bcl-2. Due to the fact several other genes liable for anti-apoptosis such as BFL-1 and c-myc have been also determined as immediate transcriptional targets of significant WT1 isoforms [16, 17], Ex4a(+)WT1-induced apoptosis may
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